Jan Karpisek was born in 1981 in Jihlava, grew up in the South Bohemian town of Trebon.
He now lives in Brno. Between 1999 and 2005 Karpisek studied at the Faculty of Fine Arts of Brno University of Technology,
at a studio led by Professor Martin Mainer, where he also worked as a technical assistant.
He then spent a half year in the art studio of performance of Professor Tomas Ruller.

Karpisek's work is characterized by topics such as, effluxion, the erotic, and, above all, spirituality.
He is deeply concerned with meditation and a number of his paintings are records of perception of the body system and soul;
however, his paintings show no formal unity. Karpisek's style sometimes evokes naivism or the grotesque,
and at other times is similar to a gestic abstraction.
Karpisek is also concerned with action painting and conceptual performance painting.
As a matter of fact, the topic of his bachelor and master work was time.
He won the Prize of Dean 2003 for his bachelor work; his large-format paintings of Hartung's character.
In 2004, Karpisek was awarded second place in the students' competition Artkontakt.
His work Mars was bought in the same year by the National Gallery in Prague and presented in IBCA 2005 in Prague.
He is a member of the art group Svitava